I have darted 1600 pound cattle with 1 cc of triple strength mixed 9:1 and had them go OUT. It depends a lot on temperment. If your animals are calm and more domesticated, they can go out good on minimal drugs. I once gave a Whole bottle of the same mix to an old stubborn cow, she got a little drowsy but never laid down. When dealing with large animals I think knowing temperment is key.