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what if there was a live test for cwd? other than biopsy

Joined Feb 2013
780 Posts | 1+
Markleville IN
I have found some interesting things in reading up on CW D. there was a live test developed for people for CJD, prion disease people get from BSE. using quaking technology they developed a blood test in people and they said it could be used for any prion disease including CWD and was inexpensive. it is hard for me to understand why nobody has grabbed on to this idea yet for CW D. the first article that I read was written in 2011.

as I see it this could change the face of CWD for deer farmers. why must we continually run from something when we could hit face on. I could see this used in conjunction with testing of heads. if a farmer has a positive on a head then the whole herd could be tested via blood test and the ones that are positive weeded out. this would be a far cry from destruction of a whole herd.

or a person could incorporate it with their TB and brucellosis testing every three years.

or before a deer is moved to another state it has to be tested

we should be using these positive herds for education purposes not destruction

these are just some ideas that I've come up with off the top of my head I would like to see other peoples discussion on this.

we need to quit running from CW D and hit head on, until then everyone will want to close their borders.



Jerrilee
 
Jerilee, could you follow up on this? It would be good to have more info on this. We have been suggesting this for a long time to help out the Brakke herd in Iowa. The Brakke herd would be a perfect opportunity, to use this for research, and prove a live test. If we had a live test, CWD would be a non-issue, and the politics of the disease would be gone.

Gary
 
Jerilee can you please post where you found the information you posted above?

Here is another ? for you Why is it that the dnr can use a rectal biopsy to determine if and animal has cwd but we can not ?
 
Gary,



below are a few articles that I found. My question is if they know their limitation in selling this to human medicine, why haven't they explored selling this to the animal industry,or have they? I found a young grad student on linkden that has helped with quaking research at CSU , I sent him a message. I will let you know if I hear back from him.



Excerpt from the last study.



The RT-QuIC is a rapid prion detection assay that is more amenable to high-throughput applications than the original QuIC and much less prone to generate spontaneous, unseeded positive reactions than the ASA assay. The sensitivity of the RT-QuIC is similar to the in vivo bioassay in hamsters, but is roughly 50–200 times faster and much less expensive.



The ability to detect prions rapidly and sensitively would be an important asset in managing TSEs. Early prion detection in individuals is critical to the prevention of spread and the initiation of potential treatments. Prions can be found in a wide variety of tissues and accessible bodily fluids from infected mammalian hosts, including blood [12]–[17], breast milk [18], [19], saliva [15], [20], urine [21], [22], feces [23], and nasal fluids [24].





http://www.nature.com/news/2011/110130/full/news.2011.59.html



http://www.google.com/url?sa=t&rct=...94CwAw&usg=AFQjCNFudSSmIVQB17vp9lziDU3nE7E03g



http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1001217



http://jvi.asm.org/content/85/3/1396.abstract



Jerrilee
 
jerrilee cave said:
I have found some interesting things in reading up on CW D. there was a live test developed for people for CJD, prion disease people get from BSE. using quaking technology they developed a blood test in people and they said it could be used for any prion disease including CWD and was inexpensive. it is hard for me to understand why nobody has grabbed on to this idea yet for CW D. the first article that I read was written in 2011.

as I see it this could change the face of CWD for deer farmers. why must we continually run from something when we could hit face on. I could see this used in conjunction with testing of heads. if a farmer has a positive on a head then the whole herd could be tested via blood test and the ones that are positive weeded out. this would be a far cry from destruction of a whole herd.

or a person could incorporate it with their TB and brucellosis testing every three years.

or before a deer is moved to another state it has to be tested

we should be using these positive herds for education purposes not destruction

these are just some ideas that I've come up with off the top of my head I would like to see other peoples discussion on this.

we need to quit running from CW D and hit head on, until then everyone will want to close their borders.



Jerrilee



Thank you, Jerilee!



This is exactly what we offered up to state of Iowa, National Assembly of Vets at USAHA and Dr. Clifford and Washington Congressman. I might add that the National Assembly of Vets listened and many agreed that this is just the direction we need to go. If we can test and cull for TB and find it acceptable, why not for CWD.



Rhonda
 
They don't want a live test because we would be the ones using it and seeing the benefits from it, the last thing they want is the politics to go away. In the beginning, the DNR groups saw CWD as there big break in putting a stop to cervid farming. Fortunately, the industry came up with a monitoring system that works and now the captive cervid industry has the healthiest animals out there. It drives them crazy

to see more and more people high fencing property and the landowners having control of the deer instead of the DNR. Would anyone let these groups run there farm or business, heck no, why would anyone let them manage there deer if they could do it themselves and do it better. The reason I started raising deer a few years ago was because on my farm I have around 1,000 wild whitetails that live there and EAT hundreds of thousands of dollars worth of feed and crops. Our state will not issue any buck tags for non-residents because they don't want any commercialized deer hunting in the state, they would rather have them die from EHD, cars, starvation, etc. then have a landowner get paid money by a non-resident for a deer hunt. If I'm going to feed deer, I would rather it be mine and not the DNR's deer. Bottom line, these DNR groups and the Wildlife Federation are the biggest opponents of any type of commercial hunting, low fence or high fence. The country has gone through some huge changes over the last decade with these groups in negative ways such as introducing wolves and decimating the elk and mule deer population out west, the Wisconsin CWD zone deer eradication program gone wrong, Black Hills SD mountain lion over population and Wind Cave National Park CWD elk herd release into the wild just to name a few. These groups have lost most of what little credibility they may have had.
 
At our last state cervid advisory meeting last winter, I asked Dr Anderson about the rectal biopsy test, and it's success. He said it was about 70% accurate. I asked him if the old TB test was as accurate, he said no, the TB test is only about 50% accurate. So why is the TB test federally accepted, and not the rectal biopsy? The test you are talking about would be great !!! We could test them when we pull blood for our bruc. tests. Even if there was a false positive, we could cull out the positives, and have a truly certified "CWD Free" herd.

Gary
 
I found this statement on the Connecticut's Dept of Energy & Environment.



Other statements made on this site seem outlandish but this statement provided by a Government agency seems to be very interesting.



How is CWD diagnosed?

Prior to 2008, the only method to definitively diagnose CWD was to examine the brain, tonsils, or lymph nodes in a laboratory. No live-animal test, vaccine, or treatment for CWD existed. In 2008, researchers from the USDA-APHIS and Colorado State University evaluated and validated the first live rectal-tissue biopsy method for detecting chronic wasting disease (CWD) in captive and wild elk. The live rectal biopsy test appears to be nearly as accurate as a post-mortem diagnostic test. The key advantage to the rectal biopsy test is that it can be performed on live animals. With this technique, managers can detect CWD in animals not showing any signs of the disease and, thus, remove them to decrease the likelihood of infecting other individuals. This new live test will improve management and control of the disease, especially in captive settings.
 
Jeff, Can you get the site, or cut and paste it. Good ammo for us. The time and energy we are wasting on a standards program, should be spent in forcing them to approve accepted tests for a live test. An approved live test would solve most all our problems. If we could use these live tests in a case like Brakkes, where they would not have to depopulate. Wouldn't that be great !!!!

Gary
 
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Chronic Wasting Disease



Captive deer infected with chronic wasting disease.

Photo courtesy of Dr. Terry Kreeger, WY Game and Fish Department

What is Chronic Wasting Disease?

Chronic wasting disease (CWD) is a neurological disease (brain and nervous system) that belongs to a family of diseases known as transmissible spongiform encephalopathies (TSE). This disease attacks the brains of deer, elk and moose and produces small lesions that eventually result in death. CWD is similar to another TSE disease, scrapie in sheep. No evidence exists that CWD affects humans or livestock.



Is CWD a new disease?

CWD was first recognized in captive mule deer in Colorado in the late 1960s, but was not identified as a TSE until the 1970s. CWD was first documented in wild elk in Colorado in 1981. Its discovery in wild deer in south-central Wisconsin in 2002 generated heightened attention from wildlife managers, hunters, and others interested in deer. CWD poses a significant threat to the deer and elk of North America and, if unchecked, could dramatically alter the future management of these species.



Why should we be concerned about CWD?

CWD is a relatively new disease and, consequently, there are a lot of unknowns. CWD does not cause an immediate widespread die-off of deer, but there may be long-term impacts to the herd if the disease is allowed to spread. Some scientists who have tried to predict the outcome on a deer population have described the disease as a 30 to 50-year epizootic with a potential to extirpate local populations. Others believe that the impacts might not be that severe. There are no proven solutions to eradicating the disease once present in wild populations. In addition, efforts by the state to contain or eradicate the disease are extremely costly and labor intensive.



How does CWD spread?

The method of CWD transmission is unknown, however there is strong evidence to suggest that abnormally-shaped proteins called "prions" are responsible. The agent responsible for this disease may spread directly through animal to animal contact or indirectly through soil or other surface to animal contact. It is thought that the most common mode of transmission from an infected animal is via saliva and feces. A recent study confirms that CWD prions can be shed into the enviroment in feces from animals showing no clinical signs of the disease and can contaminate the soil, leading to infection in other animals. CWD can be spread from region to region by the movement of captive deer or through the improper disposal of a harvested deer transported from a CWD infected area.



Where has CWD been found?

Prior to 2005, the disease had only been found in North America west of Illinois. CWD is known to occur in both wild and captive deer or elk. In 2005, CWD was documented in captive and wild herds in New York and in wild herds in West Virginia. Since then, it has been discovered in several other states. CWD has not been found in Connecticut or New England. The first reported case of wild moose infected with CWD occurred in Colorado in September 2005. Because moose do not congregate like deer and elk, cases of CWD in moose are expected to remain low.



What is being done about CWD in Connecticut?

Connecticut and all other northeastern states have taken measures to prevent the spread of CWD. The Connecticut Department of Energy & Environmental Protection (DEEP) has taken the following CWD management actions:



Connecticut, along with many other states, has banned the importation of live cervids (species in the deer/elk family) across state lines.

In fall 2003, the DEEP, in cooperation with the UCONN Wildlife Conservation Research Center, initiated a surveillance program to determine if CWD existed in Connecticut. The program included testing deer using random surveillance of hunter-harvested and road-killed deer, and targeted surveillance of suspect animals (exhibited some symptoms consistent with CWD). Through random surveillance, over 230 samples were collected statewide and all tested negative for CWD. Deer were sampled from every county and deer management zone in the state. The extent of random sampling conducted in 2003 provides a high degree of confidence that CWD is not present in Connecticut. Through targeted surveillance, 4 suspect wild deer were collected and all tested negative for CWD (3 were hit by a vehicle and initially survived; 1 was an abandoned fawn being rehabilitated at a captive facility).

Connecticut Deer Management Zones





In 2004, 298 randomly collected deer were tested for CWD from Deer Management Zone (DMZ) 11. Sampling efforts were focused in DMZ 11 because of the density of deer, relatively high number of captive deer facilities (6), and its close proximity to New York (New York has over 400 captive deer facilities with almost 10,000 deer and elk). Additionally, 6 suspect animals were collected and tested for CWD. All samples tested negative for CWD.

From 2005-2008, a CWD surveillance program approved by USDA-APHIS was designed to focus sampling efforts in areas that were considered high and moderate risk. During this 4-year period, a total of 2,564 testable samples were collected from deer harvested during the archery, shotgun/rifle, or crop damage season and from deer found on roadways throughout the state. A total of 1,140 were collected from the high-risk area and 1,424 from the moderate-risk area. Through targeted surveillance, 23 suspect animals were collected by Department staff. The DEEP also depopulated 2 small herds of wild white-tailed deer that were possessed illegally at 2 captive cervid facilities. All samples were tested at the University of Connecticut’s Department of Pathobiology and Veterinary Science in Storrs, CT (Wisconsin Veterinary Diagnostic Laboratory in 2008) and all tests were negative for CWD. Five animals collected through targeted surveillance have tested positive for rabies.

An emergency regulation that was adopted in October 2005 to address concerns about CWD became permanent in September 2007. This regulation prohibits hunters from transporting into Connecticut any deer or elk carcasses or part thereof from any state where CWD has been documented, unless the meat has been de-boned. Specific wording of the regulation follows:

“Section 26-55-4: No person shall import or possess whole carcasses or parts thereof of any deer, moose, or elk from wild or captive herds from other states or Canadian Provinces where chronic wasting disease has been confirmed, including, but not limited to, Colorado, Wyoming, Utah, New Mexico, Montana, South Dakota, Kansas, Minnesota, Wisconsin, Illinois, Nebraska, Oklahoma, New York, West Virginia, Alberta and Saskatchewan. Any additional states* and provinces where chronic wasting disease is confirmed will be published in the Department's annual Hunting and Trapping Guide and on the Department's website. This provision shall not apply to meat that's de-boned, cleaned skullcaps, hides or taxidermy mounts.�

*CWD was documented in Michigan in 2008, Virginia in 2009, and Iowa in 2012.



The DEEP, in cooperation with the University of Connecticut, collects samples from the high risk population along the New York border (DMZs 1,6, and 11) and also from moderate-risk populations in other areas of the state. Hunters interested in donating a deer head for CWD testing should keep the head cool and contact the Deer Program at the Franklin Wildlife Management Area at (860) 642-7239 or email Andy LaBonte at [email protected].

How can I tell if a deer has CWD?

In early stages of infection, animals show no symptoms. The incubation period can range from about 1-5 years. In advanced stages, infected animals begin to display abnormal behavior, such as staggering or standing with very poor posture, and carrying the head and ears in a lowered position. In later stages of the disease, infected animals become emaciated. Some symptoms of CWD also may be characteristic of other diseases and conditions (e.g., bacterial brain abscesses and epizootic hemorrhagic disease, or deer that have been injured in a deer-vehicle accident).



What should I do if I see a deer that exhibits symptoms of CWD?

Do not attempt to handle, disturb, kill, or remove the animal. Accurately document the location of the animal and immediately contact the DEEP’s 24-hour hotline at 860-424-3333. Arrangements will be made to investigate the report.



How is CWD diagnosed?

Prior to 2008, the only method to definitively diagnose CWD was to examine the brain, tonsils, or lymph nodes in a laboratory. No live-animal test, vaccine, or treatment for CWD existed. In 2008, researchers from the USDA-APHIS and Colorado State University evaluated and validated the first live rectal-tissue biopsy method for detecting chronic wasting disease (CWD) in captive and wild elk. The live rectal biopsy test appears to be nearly as accurate as a post-mortem diagnostic test. The key advantage to the rectal biopsy test is that it can be performed on live animals. With this technique, managers can detect CWD in animals not showing any signs of the disease and, thus, remove them to decrease the likelihood of infecting other individuals. This new live test will improve management and control of the disease, especially in captive settings.




What precautions should Connecticut hunters take?

Concern over CWD should not limit hunter willingness to harvest deer during the hunting season. No evidence exists that CWD affects humans or that it exists in Connecticut. Even in states where CWD is found, nobody has ever contracted CWD. Studies have shown that the abnormal prions that cause CWD do not transmit to species other than members of the deer family. However, as a precaution, public health officials recommend that humans avoid consuming meat from deer suspected of being infected with CWD. The CWD prion can be found within the meat of deer in the terminal stages of CWD. Higher levels of infected prions accumulate in tissues, such as the brain, spinal cord, spleen, lymph nodes, tonsils, and eyes, and as a precaution, contact with these items should be minimized.



Hunters should exercise the following precautions.



Minimize the use of urine-based lures. Avoid placing lures on clothes, skin, ground, or vegetation where deer can reach them.

Avoid shooting, handling, or consuming any animal that is behaving abnormally or appears to be sick.

Wear latex or rubber gloves when field dressing deer.

Minimize the handling of and do not eat the brain, spinal cord, eyes, spleen, tonsils, and lymph nodes.

De-bone meat from the animal. Do not saw through bone or cut through the brain or spinal cord (backbone).

Wash hands and instruments thoroughly after field dressing is completed. Instruments should be placed in a 1:1 bleach/water solution for an hour and left to air dry before reusing.

If you plan to hunt for deer or elk in another state, contact the state’s wildlife agency for the latest information on CWD and restrictions on transportation of harvested animals.

To avoid possible introduction of high risk tissues from CWD-infected animals harvested outside of Connecticut, hunters should return with only boned-out meat, antlers with cleaned skull caps, hides without the head, and finished taxidermy mounts. This is mandatory if the deer was taken from a state known to have CWD.

Dispose of carcasses by burying them or bringing them to landfills which accept carcasses.

Carcasses from animals harvested in CWD-infected states and disposed of in the woodlands of Connecticut could result in an outbreak of CWD in our state.

Can I have my deer tested for CWD?

The Deer Program at Franklin Wildlife Management Area will be testing some deer as part of its annual surveillance for CWD. State testing typically occurs from mid-September through the end of January. If you would like to have your deer tested free of charge during the collection period, call the Franklin Wildlife Office (860-642-7239). Prior to testing, the deer's head should be kept cool but not frozen.



How can I find out more about CWD?

Persons wanting more information on CWD are advised to visit the following web sites:



Chronic Wasting Disease Alliance

US Dept. of Agriculture, Animal Plant Health Inspection Service

Colorado Division of Wildlife

Some information on this web page was taken from CWD publications produced by other private organizations and state agencies.



Content last updated on August 1, 2012.



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SDBigBucks, you are 100% accurate on your statement. A live test would take all the politics out of the disease and that is the last thing our enemies want. They want to continue using CWD to shut our industry down one state at a time.



Jerrilee, please keep us posted if you get a response from the researcher on this blood test...thanks!
 
my feeling is we should quit whining and feeling sorry for ourselves and take the bull by the horns. We know that without a live test we are sitting ducks ready to be picked off one by one. We need to be on an all out onslaught to get a live blood test for our own good.