I've used Josh Newtons shot for e-coli for the last two years. This has worked very well for me as what was in the vaccine covered my problem.
Only my mule deer fawn when born would get it at 3 or 4 days. Losses were bad on fawns till I used that vaccine. By putting it in the does they produced the right colostrum to protect the fawns. The first year we had 100% no e-coli in the mule deer fawns and the second year we were at about 80% no problems. That was the year we didn't get the vaccine in the does at the right time because of production problems. I also had some fuso problems in fawns both whitetail and mule fawns and that also has been reduced to next to nothing.
I know some other people that didn't have that same good luck as I did but that is because their problem wasn't in or covered in that vaccine it's as simple as that.