Father to daughter ok?

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We do it all the time with good success. See the thread on outcrossing.
 
Every breeding combination imaginable has already been done. It is ok until you start seeing negative results in the offspring. At that point you must cull those animals. Line-breeding is not for everyone and tough choices need to be made sometimes. The thing you need to ask yourself is does the benefits from line-breeding out weigh the risks.
 

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