John try anything at least once! There are books written on this. One of the most important things when working inside a line is physical selection. As your desired traits come forward so do the bad ones. Here is a quick example.
You have a brother and sister born a few years ago. You are watching them grow as fawns and there growth rate is excellent, you say the old famous deer farmers last words "I can't wait till next year!"
You see that the doe fawn gets bred and fawns, but has twins and raises them with no intervention from you. They appear to be robust fawns and she has handled the nursing fine. Meanwhile her brother is cranking out one of the best yearling sets of antlers you have ever seen. Do you breed them together?
Most would say no. Why not? Because they are womb mates! Who cares. In an extremely high percentage of the times you are dealing with two eggs to make twins anyway. They both carry the DNA from mom and dad but they are very different.
If their pedigree had a low percentage of calculated inbreeding I would breed them together in a heartbeat, however if they had an already high degree of calculated inbreeding I would not. I would breed the doe out one generation and try to fix any flaws you can see she has with a complimenting buck. Her daughter would get bred a minimum of at least two season back to the brother. Those offspring then tend to become predictable and winning results.
Back to the original pairing of the womb mates, in the scenario listed above I believe the most inherent thing gained from the breeding would be maturity. In most cases with animals performing at a high level that's dollars in your pocket. There are many lines that can sight specific examples of how to get this done! Good luck in your choice.